Cytotoxic profile and peculiar reactivity with biomolecules of a novel “rule-breaker” iodo-platinum(II) complex

Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.


Publié dans:
MedChemLetters, 1, 381-385
Année
2010
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 Notice créée le 2010-12-20, modifiée le 2019-06-04


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