Loading...
research article
Transcriptional and post-transcriptional regulation of preproendothelin-1 by plaque-prone hemodynamics
2007
Plaque-prone areas are exposed to a particular hemodynamic environment characterized by a low mean shear stress value and a cyclic reversal flow. This mechanical environment, also termed oscillatory shear stress (OSS), induces the expression of several pro-atherogenic genes in the endothelial cells including the preproendothelin-1 (ppET-1) gene. The present paper investigates the molecular mechanisms of this induction.
Type
research article
Web of Science ID
WOS:000250891800013
PubMed ID
17324434
Authors
da Silva, Rafaela Fernandes
•
Chambaz, Céline
•
•
Hayoz, Daniel
•
Silacci, Paolo
Publication date
2007
Published in
Volume
194
Issue
2
Start page
383
End page
90
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 16, 2010
Use this identifier to reference this record