Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Local hemodynamics and intimal hyperplasia at the venous side of a porcine arteriovenous shunt
 
research article

Local hemodynamics and intimal hyperplasia at the venous side of a porcine arteriovenous shunt

Manos, Themistoklis A
•
Sokolis, Dimitrios P
•
Giagini, Athina T
Show more
2010
IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society

Venous anastomotic intimal hyperplasia (IH) observed in the arteriovenous shunt (AVS) has been associated with disturbed hemodynamics. This study aims to correlate hemodynamics with wall histology and wall mechanics by examining the flow field in AVS with computational fluid dynamics using experimental data taken from in vivo experiments. Input data to the computational model were obtained in vivo one month after AVS creation; adjacent vessels were submitted to histological and mechanical examination. The 3-D shunt geometry was determined using biplane angiography. Ultrasound measurements of flow rates were performed with perivascular flow probes and pressures were recorded through intravascular catheters. These data were considered as boundary conditions for calculation of the unsteady flow field. Numerical findings are suggestive of strong Dean vortices toward both vein flow exits, verified by color Doppler. The high wall shear stresses (WSSs) and their gradients appear to be related to areas of IH and vessel wall stiffening, as evidenced in preliminary histological and mechanical studies of the venous wall. Additionally, suture line hyperplasia seems to be aggravated by the high WSS gradients noted at the transition line from graft to vein.

  • Details
  • Metrics
Type
research article
DOI
10.1109/TITB.2010.2040288
Web of Science ID

WOS:000278538300017

PubMed ID

20350847

Author(s)
Manos, Themistoklis A
Sokolis, Dimitrios P
Giagini, Athina T
Davos, Constantinos H
Kakisis, John D
Kritharis, Eleftherios P
Stergiopulos, Nikos  
Karayannacos, Panayotis E
Tsangaris, Sokrates
Date Issued

2010

Published in
IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society
Volume

14

Issue

3

Start page

681

End page

90

Subjects

Anastomosis, Surgical

•

Arteriovenous Shunt, Surgical

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LHTC  
Available on Infoscience
December 16, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/62199
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés