Our goal is to identify families of relations that are useful for reasoning about software. We describe such families using decidable quantifier-free classes of logical constraints with a rich set of operations. A key challenge is to define such classes of constraints in a modular way, by combining multiple decidable classes. Working with quantifierfree combinations of constraints makes the combination agenda more realistic and the resulting logics more likely to be tractable than in the presence of quantifiers. Our approach to combination is based on reducing decidable fragments to a common class, Boolean Algebra with Presburger Arithmetic (BAPA). This logic was introduced by Feferman and Vaught in 1959 and can express properties of uninterpreted sets of elements, with set algebra operations and equicardinality relation (consequently, it can also express Presburger arithmetic constraints on cardinalities of sets). Combination by reduction to BAPA allows us to obtain decidable quantifierfree combinations of decidable logics that share BAPA operations. We use the term Calculus of Data Structures to denote a family of decidable constraints that reduce to BAPA. This class includes, for example, combinations of formulas in BAPA, weak monadic second-order logic of k-successors, two-variable logic with counting, and term algebras with certain homomorphisms. The approach of reduction to BAPA generalizes the Nelson-Oppen combination that forms the foundation of constraint solvers used in software verification. BAPA is convenient as a target for reductions because it admits quantifier elimination and its quantifier-free fragment is NP-complete. We describe a new member of the Calculus of Data Structures: a quantifier-free fragment that supports 1) boolean algebra of finite and infinite sets of real numbers, 2) linear arithmetic over real numbers, 3) formulas that can restrict chosen set or element variables to range over integers (providing, among others, the power of mixed integer arithmetic and sets of integers), 4) the cardinality operators, stating whether a given set has a given finite cardinality or is infinite, 5) infimum and supremum operators on sets. Among the applications of this logic are reasoning about the externally observable behavior of data structures such as sorted lists and priority queues, and specifying witness functions for the BAPA synthesis problem. We describe an abstract reduction to BAPA for our logic, proving that the satisfiability of the logic is in NP and that it can be combined with the other fragments of the Calculus of Data Structures.