Wound repair and regeneration
The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately become activated and are synchronized to respond. In human adults, the wound repair process commonly leads to a non-functioning mass of fibrotic tissue known as a scar. By contrast, early in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. Some organisms, however, retain the ability to regenerate tissue throughout adult life. Knowledge gained from studying such organisms might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century.
Keywords: Multipotent Stem-Cells ; Marrow-Derived Cells ; Growth-Factor-Beta ; Hair-Follicles ; Limb-Regeneration ; Tissue-Repair ; Transcriptional Control ; Keratinocyte Migration ; Inflammatory Cells ; Epithelial Repair
Record created on 2010-11-30, modified on 2016-08-09