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research article
A formal total synthesis of the marine alkaloid aaptamine
Larghi, Enrique L.
•
Obrist, Blaise V.
•
Kaufman, Teodoro S.
2008
A new strategy for the synthesis of benzo[de][1,6]naphthyridine derivative 2,3,3a,4,5,6-hexahydroaaptamine, which involves the construction of the isoquinoline ring after elaboration of the quinoline moiety, is described. Since 2,3,3a,4,5,6-hexahydroaaptamine has been previously synthesized as a key intermediate en route to the marine alkaloid aaptamine, access to this compound represents a formal total synthesis of the natural product. (c) 2008 Elsevier Ltd. All rights reserved.
Type
research article
Web of Science ID
WOS:000256179700046
Authors
Larghi, Enrique L.
•
Obrist, Blaise V.
•
Kaufman, Teodoro S.
Publication date
2008
Published in
Volume
64
Start page
5236
End page
5245
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 30, 2010
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