Sustained Effects of Nonallele-Specific Huntingtin Silencing

Objective: Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (htt) protein. No cure is available to date to alleviate neurodegeneration. Recent studies have demonstrated that RNA interference represents a promising approach for the treatment of autosomal dominant disorders. But whether an allele-specific silencing of mutant htt or a nonallele-specific silencing should be considered has not been addressed.


Published in:
Annals Of Neurology, 65, 3, 276-285
Year:
2009
Publisher:
Wiley-Blackwell
ISSN:
0364-5134
Keywords:
Laboratories:




 Record created 2010-11-30, last modified 2018-03-17


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