The purpose of this study was to evaluate a new polymer-based and magnetic resonance (MR) imaging-compatible guide wire for its application in MR-guided endovascular interventions, particularly for interventional peripheral MR angiography in swine experiments in vivo. A passive device tracking method tailored to the specific conditions of peripheral MR angiography was developed. Near-real-time visualization of the guide wire was accomplished in vivo in the carotid artery, aorta, heart, and iliac arteries of two domestic pigs. Results show great potential for this guide wire in aiding the realization of interventional peripheral MR angiography in humans.