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  4. Nanostructured Ceramic Coatings for Drug Delivery
 
conference paper

Nanostructured Ceramic Coatings for Drug Delivery

Dittmar, Karin
•
de Labrouhe, Arnaud Tourvieille
•
Piveteau, Laurent-Dominique
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2009
Advances In Material Design For Regenerative Medicine, Drug Delivery And Targeting/Imaging
Symposium on Advances in Material Design for Regenerative Medicine, Drug Delivery and Targeting/Imaging held at the 2008 MRS Fall Meeting

Drug eluting stents (DES) have been successfully implemented in clinical practice in the treatment against coronary artery disease. Compared to the implantation of bare metal stents, restenosis rates decreased significantly after stenting of DES into coronary arteries [1, 2, 3]. This project aims at creating a novel, structured, ceramic drug delivering coating for stent implants. In the following, the preparation of a titanium dioxide (TiO2) film With macroporous drug reservoirs in a mesoporous bulk ceramic is shown. The film is predominantly composed of anatase. The broad pore size distribution has a median pore width below 100 nm. The open porosity of the mesoporous bulk, which is greater than 50%, and the embedded macropores were successfully loaded with Paclitaxel (PTX). The quantity of drug loaded reaches values up to 1.2 mu g/mm(2). The continuous release of the agent into water extends over I month. The biocompatibility of the non PTX-loaded, nanostructured coating tested with primary bovine endothelial cells shows good results regarding the number of living cells, the cell vitality and morphology.

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Type
conference paper
Web of Science ID

WOS:000273377400008

Author(s)
Dittmar, Karin
de Labrouhe, Arnaud Tourvieille
Piveteau, Laurent-Dominique
Hofmann, Heinrich  
Date Issued

2009

Publisher

Materials Research Society, 506 Keystone Drive, Warrendale, Pa 15086-7573 Usa

Published in
Advances In Material Design For Regenerative Medicine, Drug Delivery And Targeting/Imaging
Series title/Series vol.

Materials Research Society Symposium Proceedings; 1140

Start page

51

End page

57

Subjects

Titanium-Oxide Films

•

Nanocrystalline Tio2

•

Eluting Stents

•

Nanotopography

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LTP  
Event nameEvent placeEvent date
Symposium on Advances in Material Design for Regenerative Medicine, Drug Delivery and Targeting/Imaging held at the 2008 MRS Fall Meeting

Boston, MA

Dec 01-03, 2008

Available on Infoscience
November 30, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/59495
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