Solution phase combinatorial synthesis of arylpiperazines

• Published in: Tetrahedron Letters (ISSN: 00404039), vol. 38, num. 23, p. 4091-4094
• Elsevier, 1997

A solution phase combinatorial synthesis of aryl piperazines 1 and 2 is described based on the S(N)Ar reaction and Schotten-Baumann acylation. The use of excess reagent is allowed and pure arylpiperazines 1 and 2 were obtained by simple acid/base washing.

Reference

• EPFL-ARTICLE-158317
• doi:10.1016/S0040-4039(97)00831-9

Record created on 2010-11-25, modified on 2017-05-12