Solution phase combinatorial synthesis of arylpiperazines

Neuville, Luc; Zhu, Jieping

doi:10.1016/S0040-4039(97)00831-9

Solution phase combinatorial synthesis of arylpiperazines

A solution phase combinatorial synthesis of aryl piperazines 1 and 2 is described based on the S(N)Ar reaction and Schotten-Baumann acylation. The use of excess reagent is allowed and pure arylpiperazines 1 and 2 were obtained by simple acid/base washing.

Published in:

Tetrahedron Letters, 38, 23, 4091-4094

Year:

1997

Publisher:

Elsevier

ISSN:

00404039

DOI:

10.1016/S0040-4039(97)00831-9

Laboratories:

LSPN