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research article
An efficient stereoselective and stereodivergent synthesis of (2R,3R)- and (2R,3S)-3-hydroxypipecolic acids
2000
Asymmetric syntheses of (2R,3R) and (2R,3S)-3-hydroxypipecolic acids are reported featuring a key diastereoselective addition of Büchi's Grignard reagent to the chiral serinal Image -5. Based on conformational analysis, a stereocontrolled reduction of piperidin-3-one (15) to cis 2,3-disubstituted piperidine (16) is also described.
Type
research article
Authors
Publication date
2000
Publisher
Published in
Volume
41
Issue
36
Start page
7033
End page
7036
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 25, 2010
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