A concise and efficient synthesis of protected actinoidic acid, the degradation product of vancomycin

• Published in: Tetrahedron Letters, vol. 34, num. 46, p. 7401-4
• Publication date: 1993

Protected actinoidic acid I, one of the degrdn. products of vancomycin, has been efficiently synthesized by a convergent route which is amenable to large scale application as well as to asym. synthesis. [on SciFinder (R)]

Keywords: Coupling reaction (biaryl ; in prepn. of vancomycin fragment actinoidic acid) ; actinoidic acid vancomycin fragment

Note:

CAN 120:164870

34-3

Amino Acids, Peptides, and Proteins

Inst. Chim. Subst. Nat.,CNRS,Gif-sur-Yvette,Fr.

Journal

0040-4039

written in English.

123-08-0P (4-Hydroxybenzaldehyde); 124-68-5P (2-Amino-2-methyl-1-propanol); 2973-76-4P (3-Bromo-4-hydroxy-5-methoxybenzaldehyde); 23030-39-9P (Benzene, 1-bromo-2,3,5-trimethoxy-); 36873-96-8P (2,3,5-Trimethoxybenzoic acid); 61654-67-9P (1,4-Benzenediol, 2-bromo-6-methoxy-); 119098-80-5P; 153335-56-9P; 153335-57-0P; 153335-58-1P; 153335-59-2P; 153335-60-5P; 153335-61-6P Role: SPN (Synthetic preparation), PREP (Preparation) (intermediate in prepn. of protected actinoidic acid deriv.); 58178-44-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 121-33-5 (4-Hydroxy-3-methoxybenzaldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (reactant, in prepn. of protected actinoidic acid deriv.)

Reference

• EPFL-ARTICLE-158211
• doi:10.1016/S0040-4039(00)60137-5

Record created on 2010-11-25, modified on 2017-05-12