Synthesis of model of phomopsin-ustiloxin-type antimitotic agents

An intramol. SNAr reaction was applied to the synthesis of a 13-membered meta-cyclophane that is the structural core of phomopsin and ustiloxin-type antimitotics. Two types of facile beta -elimination processes are also presented. [on SciFinder (R)]


Published in:
Synlett, 9, 1363-1365
Year:
2000
Keywords:
Note:
CAN 134:17720
34-3
Amino Acids, Peptides, and Proteins
Institut de Chimie des Substances Naturelles, CNRS,Gif-sur-Yvette,Fr.
Journal
0936-5214
written in English.
309714-47-4P Role: BYP (Byproduct), PREP (Preparation) (prepn. of meta-cyclophane structural cores of antimitotic phomopsins and ustiloxins); 64925-80-0 (Phomopsin A); 143557-93-1 (Ustiloxin A); 158243-18-6 (Ustiloxin D) Role: MSC (Miscellaneous) (prepn. of meta-cyclophane structural cores of antimitotic phomopsins and ustiloxins); 141-43-5 (2-Hydroxyethylamine); 2788-84-3 (Methyl L-serinate); 4070-48-8 (Methyl L-valinate); 171978-33-9; 309714-51-0 Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of meta-cyclophane structural cores of antimitotic phomopsins and ustiloxins); 309714-43-0P; 309714-44-1P; 309714-45-2P; 309714-48-5P; 309714-49-6P; 309714-50-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of meta-cyclophane structural cores of antimitotic phomopsins and ustiloxins); 309714-46-3P; 309714-52-1P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of meta-cyclophane structural cores of antimitotic phomopsins and ustiloxins)
Laboratories:




 Record created 2010-11-25, last modified 2018-03-17


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