Infoscience

Journal article

A Novel Multicomponent Synthesis of Polysubstituted 5-Aminooxazole and Its New Scaffold-Generating Reaction to Pyrrolo[3,4-b]pyridine

A novel three-component synthesis of 5-aminooxazoles is reported. Its subsequent reaction with alpha ,beta -unsatd. acyl chloride leads to polysubstituted pyrrolopyridines. A triple domino process, acylation/IMDA/retro-Michael cycloreversion, was involved in the latter process. The methodol. allows the quick prepn., from simple and readily available inputs, of highly functionalized title compds. not easily accessed by other methods. [on SciFinder (R)]

    Keywords: aminooxazole prepn reaction acyl chloride; pyrrolopyridine prepn

    Note:

    CAN 134:326420

    28-2

    Heterocyclic Compounds (More Than One Hetero Atom)

    Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.

    Journal

    1523-7060

    written in English.

    100-81-2 (3-Methylbenzylamine); 110-91-8 (Morpholine); 111-71-7 (Heptanal); 120-20-7 (3,4-Dimethoxyphenethylamine); 123-72-8 (Butanal); 140-75-0 (4-Fluorobenzylamine); 2393-23-9 (4-Methoxybenzylamine); 2577-48-2; 2780-89-4 (Methyl 6-aminohexanoate); 6688-11-5 (Formylcyclooctane); 22440-58-0; 34446-64-5; 34967-24-3 (3,5-Dimethoxybenzylamine); 66130-92-5; 85059-48-9; 336105-88-5 Role: RCT (Reactant), RACT (Reactant or reagent) (multicomponent synthesis of polysubstituted aminooxazoles and prepn. of pyrrolopyridines); 336105-90-9P; 336105-92-1P; 336105-94-3P; 336105-95-4P; 336105-96-5P; 336105-97-6P; 336105-98-7P; 336105-99-8P; 336106-17-3P; 336106-18-4P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (multicomponent synthesis of polysubstituted aminooxazoles and prepn. of pyrrolopyridines); 336106-00-4P; 336106-02-6P; 336106-05-9P; 336106-07-1P; 336106-09-3P; 336106-11-7P; 336106-13-9P; 336106-15-1P Role: SPN (Synthetic preparation), PREP (Preparation) (multicomponent synthesis of polysubstituted aminooxazoles and prepn. of pyrrolopyridines)

    Reference

    Record created on 2010-11-25, modified on 2016-08-08

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