Infoscience

Journal article

A one-pot four-component (ABC2) synthesis of macrocycles

A one-pot four component (ABC2) synthesis of macrocycles, e.g. I, is reported. This novel one-pot multicomponent synthesis delivers at least three elements of diversity into the final macrocycles. The overall process leads to the creation of six chem. bonds with the concomitant formation of two oxazole groups as part of a new macrocycle, and thus involves a large increase in mol. complexity. The synthesis is ecol. benign and atom economic since only two mols. of water are lost in this rather complex bond-forming process. [on SciFinder (R)]

    Keywords: Condensation reaction; Green chemistry (one-pot four-component (ABC2) synthesis of macrocycles); Macrocyclic compounds Role: SPN (Synthetic preparation) ; PREP (Preparation) (one-pot four-component (ABC2) synthesis of macrocycles) ; macrocycle prepn one pot four component condensation green chem

    Note:

    CAN 139:36513

    28-23

    Heterocyclic Compounds (More Than One Hetero Atom)

    Institut de Chimie des Substances Naturelles CNRS,Gif-sur-Yvette,Fr.

    Journal

    1433-7851

    written in English.

    67-56-1 (Methanol); 108-88-3 (Toluene) Role: NUU (Other use, unclassified), USES (Uses) (one-pot four-component (ABC2) synthesis of macrocycles); 111-71-7 (Heptanal); 122-78-1 (Benzeneacetaldehyde); 1069-29-0; 1477-55-0 (1,3-Benzenedimethanamine); 1889-05-0; 2752-17-2; 541550-78-1; 541550-85-0 Role: RCT (Reactant), RACT (Reactant or reagent) (one-pot four-component (ABC2) synthesis of macrocycles); 541550-77-0P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (one-pot four-component (ABC2) synthesis of macrocycles); 3144-16-9 (Camphorsulfonic acid); 7550-35-8 (Lithium bromide); 7647-15-6 (Sodium bromide); 29671-18-9 (Trimethoxy antimony) Role: RGT (Reagent), RACT (Reactant or reagent) (one-pot four-component (ABC2) synthesis of macrocycles); 541550-79-2P; 541550-80-5P; 541550-81-6P; 541550-82-7P; 541550-83-8P; 541550-84-9P Role: SPN (Synthetic preparation), PREP (Preparation) (one-pot four-component (ABC2) synthesis of macrocycles)

    Reference

    Record created on 2010-11-25, modified on 2016-08-08

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