Journal article

Total synthesis of the marine natural product (-)-cribrostatin 4 (renieramycin H)

The cytotoxic title compd. (-)-cribrostatin 4 (I) was synthesized from five readily available starting materials in a longest linear sequence of 21 steps and 4.3% overall yield. The key step in the construction of the pentacyclic core of I was a domino sequence involving beta elimination and an intramol. phenolic Mannich reaction. [on SciFinder (R)]


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