Abstract

Palladium-catalyzed intramol. Suzuki-Miyaura reaction of linear tripeptide afforded the 16-membered DEFG ring of complestatin I in good yield with an excellent atropdiastereoselectivity. Acidic treatment of I triggers a stereospecific rearrangement leading to the corresponding DEFG ring II of chloropeptin I. [on SciFinder (R)]

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