Development of multicomponent and domino reactions based on alpha -isocyanoacetamide and 5-aminooxazole

A review. This account reviews the synthesis of functionalized isocyanides, including isocyanoacetate and isocyanoacetamide derivs., and their application in multicomponent and domino reactions. Among these reaction, the three-component condensation of isocyanoacetamides with aldehydes and primary or secondary amines giving access to substituted 5-aminooxazoles is discussed in detail. The use of isocyanoacetamides and 5-aminooxazoles in the synthesis of fused heterocycles, such as pyrrolofurans, furopyridines and pyrrolopyridines, and macrolactams is also described. [on SciFinder (R)]


Published in:
Seminars in Organic Synthesis, "A. Corbella" Summer School, 33rd, Gargnano, Italy, June 23-27, 2008, 11-36
Year:
2008
Keywords:
Note:
CAN 151:550448
28-0
Heterocyclic Compounds (More Than One Hetero Atom)
Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.
Conference; General Review
written in English.
51641-98-6DP (Isocyanoacetamide); 97958-46-8DP (5-Aminooxazole) Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (multicomponent and domino reactions based on alpha -isocyanoacetamide and 5-aminooxazole)
Laboratories:




 Record created 2010-11-25, last modified 2018-03-17


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