Synthesis of L-3-hydroxy-4-methoxy-5-methylphenylalanol

The L-3-hydroxy-4-methoxy-5-methylphenylalanol, a common subunit of ecteinascidin and safracin family alkaloids, was synthesized from L-tyrosine in eight steps with an overall yield of 50%. [on SciFinder (R)]


Published in:
Synlett, 3, 466-468
Year:
2009
Keywords:
Note:
CAN 150:515329
31-2
Alkaloids
Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.
Journal
0936-5214
written in English.
60-18-4 (L-Tyrosine); 13139-17-8 Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of hydroxy-methoxy-methylphenylalanol starting from L-tyrosine via Friedel-Crafts acylation-methylation-Suzuki-Miyaura coupling reaction-Baeyer-Villiger oxidn.-hydrogenolysis); 262360-92-9P; 851915-13-4P; 1150635-46-3P; 1150635-53-2P; 1150635-56-5P; 1150635-60-1P; 1150635-61-2P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of hydroxy-methoxy-methylphenylalanol starting from L-tyrosine via Friedel-Crafts acylation-methylation-Suzuki-Miyaura coupling reaction-Baeyer-Villiger oxidn.-hydrogenolysis); 686776-27-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of hydroxy-methoxy-methylphenylalanol starting from L-tyrosine via Friedel-Crafts acylation-methylation-Suzuki-Miyaura coupling reaction-Baeyer-Villiger oxidn.-hydrogenolysis)
Laboratories:




 Record created 2010-11-25, last modified 2018-01-28


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