Combination of lithium chloride and hexafluoroisopropanol for Friedel-Crafts reactions
2009
Abstract
A combination of weak Lewis acid (LiCl) and weak Bronsted acid (hexafluoroisopropanol, HFIP) promotes efficiently the Friedel-Crafts reaction of electron-rich arom. compds. with Et glyoxylate. [on SciFinder (R)]
Details
Title
Combination of lithium chloride and hexafluoroisopropanol for Friedel-Crafts reactions
Author(s)
Willot, Matthieu ; Chen, Jin Chun ; Zhu, Jieping
Published in
Synlett
Issue
4
Pages
577-580
Date
2009
ISSN
0936-5214
Keywords
Friedel-Crafts reaction; Friedel-Crafts reaction catalysts (Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); Lewis acids Role: CAT (Catalyst use); USES (Uses) (Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); Alcohols Role: SPN (Synthetic preparation); PREP (Preparation) (aralkyl; Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); Aromatic hydrocarbons Role: RCT (Reactant); SPN (Synthetic preparation); PREP (Preparation); RACT (Reactant or reagent) (electron-rich; Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); Carboxylic acids Role: SPN (Synthetic preparation); PREP (Preparation) (hydroxy; esters; Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); arene glyoxylate Friedel Crafts hydroxyalkylation lithium chloride fluoroisopropanol catalyst; arylglycolate prepn; mandelate prepn
Note
CAN 151:7836
21-2
General Organic Chemistry
Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.
Journal
written in English.
920-66-1 (Hexafluoroisopropanol); 7447-41-8 (Lithium chloride) Role: CAT (Catalyst use), USES (Uses) (Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); 96-54-8 (N-Methylpyrrole); 120-72-9 (Indole); 121-69-7 (N,N-Dimethylaniline); 151-10-0 (1,3-Dimethoxybenzene); 533-31-3 (3,4-Methylenedioxyphenol); 924-44-7 (Ethyl glyoxylate); 2033-89-8 (3,4-Dimethoxyphenol); 2138-48-9 (3-Isopropyl-1,2-benzenediol); 244126-41-8; 924726-98-7; 925451-68-9 Role: RCT (Reactant), RACT (Reactant or reagent) (Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); 3616-48-6P; 10367-41-6P; 74283-75-3P; 151453-13-3P; 474433-56-2P; 474433-60-8P; 474433-61-9P; 874758-53-9P; 1158715-27-5P; 1158715-31-1P; 1158715-39-9P; 1158715-44-6P; 1158715-48-0P; 1158715-53-7P Role: SPN (Synthetic preparation), PREP (Preparation) (Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst)
21-2
General Organic Chemistry
Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.
Journal
written in English.
920-66-1 (Hexafluoroisopropanol); 7447-41-8 (Lithium chloride) Role: CAT (Catalyst use), USES (Uses) (Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); 96-54-8 (N-Methylpyrrole); 120-72-9 (Indole); 121-69-7 (N,N-Dimethylaniline); 151-10-0 (1,3-Dimethoxybenzene); 533-31-3 (3,4-Methylenedioxyphenol); 924-44-7 (Ethyl glyoxylate); 2033-89-8 (3,4-Dimethoxyphenol); 2138-48-9 (3-Isopropyl-1,2-benzenediol); 244126-41-8; 924726-98-7; 925451-68-9 Role: RCT (Reactant), RACT (Reactant or reagent) (Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); 3616-48-6P; 10367-41-6P; 74283-75-3P; 151453-13-3P; 474433-56-2P; 474433-60-8P; 474433-61-9P; 874758-53-9P; 1158715-27-5P; 1158715-31-1P; 1158715-39-9P; 1158715-44-6P; 1158715-48-0P; 1158715-53-7P Role: SPN (Synthetic preparation), PREP (Preparation) (Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst)
Laboratories
LSPN
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LSPN - Laboratory of synthesis and natural products
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date
2010-11-25