Combination of lithium chloride and hexafluoroisopropanol for Friedel-Crafts reactions

A combination of weak Lewis acid (LiCl) and weak Bronsted acid (hexafluoroisopropanol, HFIP) promotes efficiently the Friedel-Crafts reaction of electron-rich arom. compds. with Et glyoxylate. [on SciFinder (R)]


Published in:
Synlett, 4, 577-580
Year:
2009
Keywords:
Note:
CAN 151:7836
21-2
General Organic Chemistry
Institut de Chimie des Substances Naturelles,CNRS,Gif-sur-Yvette,Fr.
Journal
0936-5214
written in English.
920-66-1 (Hexafluoroisopropanol); 7447-41-8 (Lithium chloride) Role: CAT (Catalyst use), USES (Uses) (Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); 96-54-8 (N-Methylpyrrole); 120-72-9 (Indole); 121-69-7 (N,N-Dimethylaniline); 151-10-0 (1,3-Dimethoxybenzene); 533-31-3 (3,4-Methylenedioxyphenol); 924-44-7 (Ethyl glyoxylate); 2033-89-8 (3,4-Dimethoxyphenol); 2138-48-9 (3-Isopropyl-1,2-benzenediol); 244126-41-8; 924726-98-7; 925451-68-9 Role: RCT (Reactant), RACT (Reactant or reagent) (Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); 3616-48-6P; 10367-41-6P; 74283-75-3P; 151453-13-3P; 474433-56-2P; 474433-60-8P; 474433-61-9P; 874758-53-9P; 1158715-27-5P; 1158715-31-1P; 1158715-39-9P; 1158715-44-6P; 1158715-48-0P; 1158715-53-7P Role: SPN (Synthetic preparation), PREP (Preparation) (Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst)
Laboratories:




 Record created 2010-11-25, last modified 2018-03-17


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