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  4. Evolution of Feedback Loops in Oscillatory Systems
 
conference paper not in proceedings

Evolution of Feedback Loops in Oscillatory Systems

Hafner, Marc  
•
Köppl, Heinz
•
Wagner, Andreas
2009
3rd International Conference on Foundations of Systems Biology in Engineering (FOSBE)

Feedback loops are major components of biochemical systems. Many systems show multiple such (positive or negative) feedback loops. Nevertheless, very few quantitative analyses address the question how such multiple feedback loops evolved. Based on published models from the mitotic cycle in embryogenesis, we build a few case studies. Using a simple core architecture (transcription, phosphorylation and degradation), we define oscillatory models having either one positive feedback or one negative feedback, or both loops. With these models, we address the following questions about evolvability: could a system evolve from a simple model to a more complex one with a continuous transition in the parameter space? How do new feedback loops emerge without disrupting the proper function of the system? Our results show that progressive formation of a second feedback loop is possible without disturbing existing oscillatory behavior. For this process, the parameters of the system have to change during evolution to maintain predefined properties of oscillations like period and amplitude.

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Type
conference paper not in proceedings
ArXiv ID

1003.1231

Author(s)
Hafner, Marc  
Köppl, Heinz
Wagner, Andreas
Date Issued

2009

Subjects

Oscillators

•

feedback loops

•

evolution

•

robustness

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LANOS  
Event nameEvent placeEvent date
3rd International Conference on Foundations of Systems Biology in Engineering (FOSBE)

Denver, CO

August 9-12, 2009

Available on Infoscience
November 24, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/58294
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