Direct Alkynylation of Thiophenes: Cooperative Activation of TIPS–EBX with Gold and Brønsted Acids

United we stand! Cooperative activation of the hypervalent-iodine reagent TIPS-EBX with a gold catalyst and a Brønsted acid allowed the first direct ethynylation of thiophenes at room temperature (see scheme; TFA=trifluoroacetic acid). The obtained ethynylthiophenes are important building blocks for organic dyes and electronic materials.


Published in:
Angewandte Chemie, International Edition, 49, 40, 7304-7307
Year:
2010
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 Record created 2010-11-21, last modified 2018-03-17

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