P450-mediated electrochemical sensing of drugs in human plasma for personalized therapy

Nowadays, the concept of personalized therapy gains momentum. Pharmacogenomics, which represents a first answer to these needs, has the drawback of neglecting some variations of therapy response due to non-genetic factors. The aim of this paper is to investigate the feasibility of a non-genetic approach to personalized therapy, via the point-of-care drug monitoring in biological fluids with electrochemical biosensors. The proposed biosensor is based on the use of P450 enzymes as probe molecules, thanks to their key role in human metabolism. Multiwalled carbon nanotubes are used to enhance biosensor sensitivity. Results show how the proposed system is capable to detect drug amounts within the corresponding pharmacological ranges in human serum.


Publié dans:
Proceedings of the 6th Conference on Ph.D. Research in Microelectronics and Electronics (PRIME), 1-4
Présenté à:
6th Conference on Ph.D. Research in Microelectronics and Electronics (PRIME), Berlin, Germany, July 18-21, 2010
Année
2010
ISBN:
978-1-4244-7905-4
Mots-clefs:
Laboratoires:




 Notice créée le 2010-11-04, modifiée le 2019-03-16

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