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research article
Fluidic microstructuring of alginate hydrogels for the single cell niche
2010
Controlling alginate gel formation by diffusion of Ca2+ ions through a filter barrier, a layer-by-layer deposition technique with resolution on the size scale of a single cell is presented. It offers the possibility of exposing cells under biocompatible conditions to microheterogeneous three-dimensional environments, mimicking the layered structure of extracellular matrix in tissues.
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Braschler'10-Lab-Chip.pdf
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