Fluidic microstructuring of alginate hydrogels for the single cell niche

Controlling alginate gel formation by diffusion of Ca2+ ions through a filter barrier, a layer-by-layer deposition technique with resolution on the size scale of a single cell is presented. It offers the possibility of exposing cells under biocompatible conditions to microheterogeneous three-dimensional environments, mimicking the layered structure of extracellular matrix in tissues.


Published in:
Lab on a Chip, 10, 20, 2771-2777
Year:
2010
Publisher:
Royal Society of Chemistry
ISSN:
1473-0197
Keywords:
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 Record created 2010-11-02, last modified 2018-03-18

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