On the generation of poly(dl-lactide-co-glycolide) (PLGA) particles in microfluidic flow focusing devices (MFFD) made of Norland Optical Adhesives (NOA81)
This paper shows the generation of monodisperse PLGA micro-droplets in MFFD made of NOA 81. We also present a theory coupled to the MFFD design capable of predicting the size and frequency of the polymer-droplet formation. Chang. et al. have encapsulated nanoparticles in PLGA droplets , while Xu et al. demonstrated the capability of polydimethylsiloxane (PDMS) MFFDs to produce drug-loaded monodisperse PLGA particles and studied their drug release kinetics . However to our knowledge the coupling of theory-based design of MFFD together with extensive experimental validation has not been demonstrated yet.
Record created on 2010-10-14, modified on 2016-08-08