On the generation of poly(dl-lactide-co-glycolide) (PLGA) particles in microfluidic flow focusing devices (MFFD) made of Norland Optical Adhesives (NOA81)

This paper shows the generation of monodisperse PLGA micro-droplets in MFFD made of NOA 81. We also present a theory coupled to the MFFD design capable of predicting the size and frequency of the polymer-droplet formation. Chang. et al. have encapsulated nanoparticles in PLGA droplets [1], while Xu et al. demonstrated the capability of polydimethylsiloxane (PDMS) MFFDs to produce drug-loaded monodisperse PLGA particles and studied their drug release kinetics [2]. However to our knowledge the coupling of theory-based design of MFFD together with extensive experimental validation has not been demonstrated yet.

Presented at:
the 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Groningen, Netherlands, Oct 3-7, 2010

 Record created 2010-10-14, last modified 2018-03-17

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