It has been established that primary stability of femoral stems is a determinant of the clinical success of cementless total hip arthroplasty. Excessive interface micromotions may lead to a peri-implant fibrous tissue formation resulting in aseptic loosening of the implant . The effect of micromotion on the tissue outcome remains still unclear. However, it is becoming increasingly clear that interstitial fluid flow is the primary mechanism by which bone cells perceive changes in their mechanical environment . Therefore, to estimate the interstitial peri-implant fluid flow, a detailed measurement of simultaneously normal and tangential micromotion, is required. The objective of this study is to assess the feasibility of the micromotion measurement on human cadaveric femur with micro computed tomography.