Studies toward new anti-cancer strategies based on alpha-mannosidase inhibition

Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumour progression, suggesting that inhibitors of selected glycosidases may control cancer invasion. Following the studies on swainsonine, a natural inhibitor of Golgi -mannosidase II, which highlighted the inhibition of cellular mannosidases as a potential innovative approach for the treatment of cancer, several dihydroxylated pyrrolidines and analogues were developed as new potent inhibitors of -mannosidases II able to induce antiproliferative effects on human cancer cells.


Published in:
Chimia -Zurich-, 64, 634-639
Year:
2010
Publisher:
Schweizerische Chemische Gesellschaft
ISSN:
0009-4293
Keywords:
Laboratories:




 Record created 2010-09-21, last modified 2018-03-17


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