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research article
Studies toward new anti-cancer strategies based on alpha-mannosidase inhibition
2010
Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumour progression, suggesting that inhibitors of selected glycosidases may control cancer invasion. Following the studies on swainsonine, a natural inhibitor of Golgi -mannosidase II, which highlighted the inhibition of cellular mannosidases as a potential innovative approach for the treatment of cancer, several dihydroxylated pyrrolidines and analogues were developed as new potent inhibitors of -mannosidases II able to induce antiproliferative effects on human cancer cells.
Type
research article
Web of Science ID
WOS:000282087900003
Authors
Publication date
2010
Published in
Volume
64
Start page
634
End page
639
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
September 21, 2010
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