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  4. A single point mutation responsible for c-mos polymorphism in cancer patients.
 
research article

A single point mutation responsible for c-mos polymorphism in cancer patients.

Lidereau, R
•
Cole, S T  
•
Larsen, C J
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1987
Oncogene

A rare EcoRI restriction fragment length polymorphism (RFLP) in the 3' end of the human c-mos locus has been identified in DNA from patients with breast tumors, esophageal carcinomas and leukemias. Until now, this RFLP has not been found in normal populations, suggesting that its presence may reflect some cancer susceptibility. To characterize this RFLP, we have isolated both alleles of the c-mos locus from DNA of a breast cancer patient and determined the nucleotide sequence of the polymorphic region. Our results show that this RFLP is due to a single nucleotide substitution (T instead of C), resulting in the disappearance of EcoRI site.

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Type
research article
PubMed ID

2894001

Author(s)
Lidereau, R
Cole, S T  
Larsen, C J
Mathieu-Mahul, D
Date Issued

1987

Published in
Oncogene
Volume

1

Issue

2

Start page

235

End page

7

Subjects

Oncogenes

•

Polymorphism, Genetic

•

Polymorphism, Restriction Fragment Length

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPCOL  
Available on Infoscience
September 7, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/53288
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