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research article

Streptomycin resistance in mycobacteria.

Honoré, N
•
Cole, S T  
1994
Antimicrobial agents and chemotherapy

Streptomycin, the first antibiotic used in tuberculosis control programs, perturbs protein synthesis at the ribosome level. It is shown here that streptomycin resistance in some clinical isolates of Mycobacterium tuberculosis is associated either with missense mutations in the rpsL gene, which encodes ribosomal protein S12, or with base substitutions at position 904 in the 16S rRNA. The primary structure of the S12 protein is well conserved among the mycobacteria, even those, such as M. avium, M. gordonae, and M. szulgai, that are naturally resistant to streptomycin. This suggests that permeability barriers may be responsible for the resistance to the antibiotic.

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Type
research article
DOI
10.1128/AAC.38.2.238
PubMed ID

8192450

Author(s)
Honoré, N
Cole, S T  
Date Issued

1994

Published in
Antimicrobial agents and chemotherapy
Volume

38

Issue

2

Start page

238

End page

242

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPCOL  
Available on Infoscience
September 7, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/53251
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