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research article

Local comparison of the genomes of Mycobacterium tuberculosis and Mycobacterium leprae using the polymerase chain reaction

Philipp, W J
•
Cole, S T  
1995
FEMS microbiology letters

To facilitate comparison of the genome maps of Mycobacterium tuberculosis and M. leprae, sequence data from the M. leprae sequencing project were used to design primers suitable for the amplification of short segments from conserved genes by the polymerase chain reaction. In most cases, both organisms yielded products of identical size that were then used as probes for a comparative genomic walk. The hybridization data often, but not always, revealed a similar organization of various regions of both genomes. This approach should be useful for systematic comparisons of (myco)bacterial genomes.

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Type
research article
DOI
10.1111/j.1574-6968.1995.tb07844.x
PubMed ID

7590183

Author(s)
Philipp, W J
Cole, S T  
Date Issued

1995

Published in
FEMS microbiology letters
Volume

132

Issue

3

Start page

263

End page

9

Subjects

Genome, Bacterial

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPCOL  
Available on Infoscience
September 7, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/53234
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