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research article

The complete genome sequence of Mycobacterium bovis

Garnier, Thierry
•
Eiglmeier, Karin
•
Camus, Jean-Christophe
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2003
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS)

Mycobacterium bovis is the causative agent of tuberculosis in a range of animal species and man, with worldwide annual losses to agriculture of $3 billion. The human burden of tuberculosis caused by the bovine tubercle bacillus is still largely unknown. M. bovis was also the progenitor for the M. bovis bacillus Calmette-Guérin vaccine strain, the most widely used human vaccine. Here we describe the 4,345,492-bp genome sequence of M. bovis AF2122/97 and its comparison with the genomes of Mycobacterium tuberculosis and Mycobacterium leprae. Strikingly, the genome sequence of M. bovis is >99.95% identical to that of M. tuberculosis, but deletion of genetic information has led to a reduced genome size. Comparison with M. leprae reveals a number of common gene losses, suggesting the removal of functional redundancy. Cell wall components and secreted proteins show the greatest variation, indicating their potential role in host-bacillus interactions or immune evasion. Furthermore, there are no genes unique to M. bovis, implying that differential gene expression may be the key to the host tropisms of human and bovine bacilli. The genome sequence therefore offers major insight on the evolution, host preference, and pathobiology of M. bovis.

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Type
research article
DOI
10.1073/pnas.1130426100
PubMed ID

12788972

Author(s)
Garnier, Thierry
Eiglmeier, Karin
Camus, Jean-Christophe
Medina, Nadine
Mansoor, Huma
Pryor, Melinda
Duthoy, Stephanie
Grondin, Sophie
Lacroix, Celine
Monsempe, Christel
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Date Issued

2003

Publisher

National Academy of Sciences

Published in
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS)
Volume

100

Issue

13

Start page

7877

End page

82

Subjects

Genome, Bacterial

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPCOL  
Available on Infoscience
September 7, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/53164
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