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research article
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues
We recently reported that 3,3-dimethyl-3H-benzofuro[3,2,f][1]-benzopyran and its hydrogenated analogue are selective in vitro inhibitors of mycobacterial growth. However, their lack of in vivo activity on a murine model of Mycobacterium tuberculosis infection due to their poor bioavailability led to a structure-activity relationship investigation. We wish to report here the preparation of some structural analogues along with their biological effect on the growth of Mycobacterium smegmatis, M. tuberculosis, as well as on VERO cells for the most active compound.
Type
research article
PubMed ID
17208445
Authors
Prado, Soizic
•
Janin, Yves L
•
Saint-Joanis, Brigitte
•
Brodin, Priscille
•
Michel, Sylvie
•
Koch, Michel
•
•
Tillequin, François
•
Bost, Pierre-Etienne
Publication date
2007
Published in
Volume
15
Issue
5
Start page
2177
End page
86
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
September 7, 2010
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