Supersymmetric extensions of the Standard Model contain nontopological solitons, Q-balls, which can be stable and can be a form of cosmological dark matter. Understanding the interaction of SUSY Q-balls with matter fermions is important for both astrophysical limits and laboratory searches for these dark-matter candidates. We show that a baryon scattering off a baryonic SUSY Q-ball can convert into its antiparticle with a high probability, while the baryon number of the Q-ball is increased by two units. For a SUSY Q-ball interacting with matter, this process dominates over those previously discussed in the literature. © 2005 The American Physical Society.