research article
Infection of mice with aerosolized Mycobacterium tuberculosis: use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility
Aerosolized delivery of virulent or hypervirulent Mycobacterium tuberculosis requires careful consideration of methodology and safety. To maximize safety, we installed a nose-only aerosol apparatus that can reproducibly deliver a low dose (<100 CFU per mouse) of M. tuberculosis in a carefully designed biohazard facility.
Type
research article
PubMed ID
12200325
Author(s)
Schwebach, J Reid
Chen, Bing
Glatman-Freedman, Aharona
Casadevall, Arturo
Harb, John L
McGuire, Patrick J
Barkley, W Emmett
Bloom, Barry R
Jacobs, William R
Date Issued
2002
Published in
Volume
68
Issue
9
Start page
4646
End page
9
Subjects
Editorial or Peer reviewed
REVIEWED
Written at
OTHER
EPFL units
Available on Infoscience
September 7, 2010
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