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  4. A multidrug-resistant, acr1-deficient clinical isolate of Mycobacterium tuberculosis is unimpaired for replication in macrophages
 
research article

A multidrug-resistant, acr1-deficient clinical isolate of Mycobacterium tuberculosis is unimpaired for replication in macrophages

Timm, Juliano
•
Kurepina, Natalia
•
Kreiswirth, Barry N
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2006
The Journal of infectious diseases

Multidrug-resistant tuberculosis (MDR-TB) poses a serious threat to global public health. The mutations responsible for drug resistance in Mycobacterium tuberculosis have been identified, but what impact these mutations have on bacterial fitness is controversial. We analyzed 3 MDR strains of M. tuberculosis obtained from human immunodeficiency virus-negative patients with chronic pulmonary TB. One of these strains harbored a chromosomal deletion encompassing 15 open reading frames. Genes deleted in this strain included acr1, which encodes the virulence factor alpha-crystallin (Acr) 1, a protein that has been reported to be essential for M. tuberculosis replication in macrophages. We found that all 3 MDR isolates, including the acr1-deficient strain, replicated in cultured murine and human macrophages with the same kinetics as H37Rv, a virulent laboratory strain. These observations challenge the prevailing view that MDR bacteria are less fit than drug-susceptible bacteria and indicate that Acr1 is dispensable for bacterial growth in the human lung.

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Type
research article
DOI
10.1086/504526
PubMed ID

16703514

Author(s)
Timm, Juliano
Kurepina, Natalia
Kreiswirth, Barry N
Post, Frank A
Walther, Gabrielle B
Wainwright, Helen C
Bekker, Linda-Gail
Kaplan, Gilla
McKinney, John D  
Date Issued

2006

Published in
The Journal of infectious diseases
Volume

193

Issue

12

Start page

1703

End page

10

Subjects

Drug Resistance

•

Multiple

•

Bacterial

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPKIN  
Available on Infoscience
September 7, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/52815
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