Synthesis of Chiral Bifunctional (Thio)Urea N-Heterocyclic Carbenes

The rapid and modular synthesis of the first bifunctional N-heterocyclic carbenes bearing a (thio)urea moiety as H-bond donor group was reported. Different analogues could be accessed in seven steps from cheap (S)-pyroglutamic acid in good overall yields (14-30%). The synthesized carbenes were active catalysts in the benzoin reaction.


Published in:
Synlett, 881-884
Year:
2010
Publisher:
Georg Thieme Verlag
ISSN:
0936-5214
Keywords:
Laboratories:




 Record created 2010-04-05, last modified 2018-09-13

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