Design of lattice proteins with explicit solvent

Protein design is important to develop new drugs. As such, a knowledge of the correct model to use to design novel proteins is of the utmost importance. Here we show that a simple model where the solvent degrees of freedom are (semi)explicitly taken into account performs better than other existing models when compared to real data. Some consequences on the criteria to be used for protein design are discussed.


Published in:
Physical Review E, 66, 061911
Year:
2002
ISSN:
1095-3787
Keywords:
Laboratories:




 Record created 2010-03-22, last modified 2018-03-17


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)