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research article
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia
2009
In Alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia.
Type
research article
Authors
Grathwohl, Stefan A.
•
Kalin, Roland E.
•
•
Prokop, Stefan
•
Winkelmann, Georg
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Kaeser, Stephan A.
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Odenthal, Jorg
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Radde, Rebecca
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Eldh, Therese
•
Gandy, Sam
Publication date
2009
Publisher
Published in
Volume
12
Issue
11
Start page
1361
End page
1363
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
March 16, 2010
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