Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

In Alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia.


Published in:
Nature Neuroscience, 12, 11, 1361-1363
Year:
2009
Publisher:
Nature Publishing Group
ISSN:
1097-6256
Keywords:
Laboratories:




 Record created 2010-03-16, last modified 2018-03-17


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