Clking on PGC-1alpha to inhibit gluconeogenesis

The link between Akt activation and gluconeogenic repression remains unclear, despite many years of investigation and remarkable progress. Rodgers and colleagues now introduce us to the Clk2 kinase, an Akt substrate that can directly phosphorylate and inhibit PGC-1alpha, blunting hepatic glucose production.


Published in:
Cell Metabolism, 11, 1, 6-7
Year:
2010
Keywords:
Laboratories:




 Record created 2010-03-10, last modified 2018-03-17


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