A CMOS imager is presented which has the abil- ity to perform localized compressive sensing on-chip. In-pixel convolutions of the sensed image with measurement matrices are computed in real time, and a proposed programmable two- dimensional scrambling technique guarantees the randomness of the coefficients used in successive observation. A power and area- efficient implementation architecture is presented making use of a single ADC. A 256×256 imager has been developed as a test vehicle in a 0.18μm CIS technology. Using an 11-bit ADC, a SNR of 18.6dB with a compression factor of 3.3 is achieved after reconstruction. The total power consumption of the imager is simulated at 76.7mW from a 1.8V supply voltage.