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conference paper
Single-molecule avidin-biotin association reaction studied by force-clamp spectroscopy
2008
ULTRAMICROSCOPY
Using single-molecule force-clamp spectroscopy, where the distance between the AFM tip and the sample surface is fixed and a few parallel avidin-biotin complexes are kept stretched by a certain force, we were able to observe the formation of single avidin-biotin bonds. Perspectives to use such all approach to study association reactions at single-molecule level in the conditions resembling those characteristic for some processes in vivo (e.g. virus-cell membrane attachment) are briefly discussed. (C) 2008 Elsevier B.V. All rights reserved.
Type
conference paper
Web of Science ID
WOS:000259728000030
Authors
Publication date
2008
Published in
ULTRAMICROSCOPY
Volume
108
Start page
1135
End page
1139
Peer reviewed
REVIEWED
EPFL units
Event name | Event place | Event date |
Jeju, SOUTH KOREA | JUN 10-14, 2007 | |
Available on Infoscience
February 9, 2010
Use this identifier to reference this record