VIP and PACAP in the CNS: regulators of glial energy metabolism and modulators of glutamatergic signaling

VIP neurons are a homogeneous population of intracortical bipolar cells. They receive excitatory synapses from afferent circuits to the cortex and exert effects on neurons, astrocytes, and capillaries. Effects on the two latter cell types imply that VIP neurons can translate incoming neuronal signals into local metabolic actions. Indeed, VIP tightly regulates glycogen metabolism in astrocytes. In this cell type VIP regulates the expression of a number of genes related to energy metabolism, such as glycogen synthase. These effects of VIP involve the transcription factor family C/EBP and result in the induction of at least seven new proteins by astrocytes. The actions of VIP on neurons appear to be of a modulatory nature: thus VIP enhances glutamate-mediated neurotransmission by potentiating the effects of glutamate on arachidonic acid formation and on the induction of c-fos and on BDNF expression. These effects indicate that VIP can actually increase the strength of glutamate-mediated neurotransmission

Published in:
Annals of the New York Academy of Sciences, 865, VIP, PACAP, and related peptides: third international symposium, 213-25
Presented at:
3rd International Symposium on VIP, PACAP, and Related Peptides, Freiburg, Germany, September 17–20, 1997
The New York Academy of Sciences

 Record created 2010-01-27, last modified 2018-01-28

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