000143526 001__ 143526
000143526 005__ 20190316234653.0
000143526 0247_ $$2doi$$a10.1111/j.1755-3768.2008.01404.x
000143526 02470 $$2ISI$$a000266420700013
000143526 037__ $$aARTICLE
000143526 245__ $$aWireless contact lens sensor for intra ocular pressure monitoring: assessment on enucleated pig eyes
000143526 269__ $$a2009
000143526 260__ $$c2009
000143526 336__ $$aJournal Articles
000143526 520__ $$aPurpose: Assessment on enucleated pig eyes of a novel and minimally invasive method for the continuous monitoring of intraocular pressure (IOP), based on a novel wireless contact lens sensor (CLS). Methods: The wireless CLS is a disposable silicone soft contact lens with a sensor embedded in it, allowing the wireless measurement of changes in corneal curvature induced by IOP variations. A CLS was adapted and tested on enucleated pig eyes. To demonstrate the measurement principle of the device, the enucleated pig eye was cannulated, allowing precise control of IOP. The CLS signal was then compared to the imposed IOP. Results: First, the IOP of enucleated pig eyes was changed between 11 and 14 mmHg, simulating ocular pulsation. Then, IOP was changed with static steps of 1 mmHg between 20 and 30 mmHg to assess the reproducibility and linearity of the CLS. In both cases, measurements from the CLS and IOP showed very good correlation. A calibration graph shows that the CLS is capable of monitoring the IOP of each individual eye with a reproducibility of ± 0.2 mmHg (95% confidence interval). Conclusion: The wireless CLS shows a good functionality to monitor the IOP on enucleated pig eyes. The device is placed in the same way as a soft disposable contact lens. This device would allow a minimally invasive and continuous monitoring of IOP over prolonged periods of up to 24 hr, regardless of patient activity, thus opening up new diagnostic and therapeutic methods to manage glaucoma.
000143526 6531_ $$acontact lens
000143526 6531_ $$aglaucoma
000143526 6531_ $$atelemetry
000143526 6531_ $$atonometer
000143526 700__ $$0241612$$g102343$$aLeonardi, Matteo
000143526 700__ $$aPitchon, E.
000143526 700__ $$0240202$$g113143$$aBertsch, Arnaud
000143526 700__ $$aRenaud, Philippe$$g107144$$0240219
000143526 700__ $$aMermoud, A.
000143526 773__ $$j87$$tActa Ophthalmologica$$k4$$q433-437
000143526 8564_ $$zURL
000143526 8564_ $$uhttps://infoscience.epfl.ch/record/143526/files/Leonardi%2709-ActaOphthalmo.pdf$$zn/a$$s222557
000143526 909C0 $$xU10324$$0252064$$pLMIS4
000143526 909CO $$qGLOBAL_SET$$pSTI$$ooai:infoscience.tind.io:143526$$particle
000143526 937__ $$aLMIS4-ARTICLE-2010-002
000143526 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000143526 980__ $$aARTICLE