Pd-Catalyzed Intramolecular Oxyalkynylation of Alkenes with Hypervalent Iodine

The first example of intramolecular oxyalkynylation of nonactivated alkenes using oxidative Pd chemistry is reported. Both phenol and aromatic or aliphatic acid derivatives could be used under operator-friendly conditions (room temperature, technical solvents, under air). The discovery of the superiority of benziodoxolone-derived hypervalent iodine reagent 3d as an alkyne transfer reagent further expands the rapidly increasing utility of hypervalent iodine reagents in catalysis and is expected to have important implications for other similar processes.


Published in:
Organic Letters, 12, 2, 384-387
Year:
2010
Publisher:
American Chemical Society
ISSN:
1523-7060
Keywords:
Laboratories:




 Record created 2010-01-10, last modified 2018-03-17

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