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  4. Prostaglandins and the synergism between VIP and noradrenaline in the cerebral cortex
 
research article

Prostaglandins and the synergism between VIP and noradrenaline in the cerebral cortex

Schaad, N C
•
Schorderet, M
•
Magistretti, P J  
1987
Nature

We have previously shown that vasoactive intestinal peptide (VIP) and noradrenaline (NA) interact synergistically to increase cyclic AMP levels in mouse cerebral cortical slices. The pharmacological mechanism of this synergism is the potentiation by NA, through alpha 1 adrenergic receptors, of the stimulatory effect of VIP on cAMP formation. A similar interaction has been confirmed in guinea pig cerebral cortex and in discrete nuclei of the rat hypothalamus. Furthermore VIP and NA interact synergistically to depress the spontaneous activity of identified neurons in rat neocortex. At the cellular level, this synergistic interaction suggests that VIP- and NA-containing neuronal systems may converge, at least in part, on the same target cells to increase cAMP levels in the cerebral cortex. At the molecular level, the interaction may occur at various steps in signal transduction, between receptors, intramembrane transduction processes or intracellular effector mechanisms. Here we report that the alpha 1-adrenergic potentiation of the increases in cAMP elicited by VIP involves the formation of arachidonic acid metabolites and is mimicked by prostglandins F2 alpha and E2.

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Type
research article
DOI
10.1038/328637a0
PubMed ID

3039374

Author(s)
Schaad, N C
Schorderet, M
Magistretti, P J  
Date Issued

1987

Published in
Nature
Volume

328

Issue

6131

Start page

637

End page

40

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
LNDC  
Available on Infoscience
January 8, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/45316
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