000143219 001__ 143219
000143219 005__ 20181228151103.0
000143219 022__ $$a0028-0836
000143219 02470 $$2PMID$$a3039374
000143219 0247_ $$2doi$$a10.1038/328637a0
000143219 037__ $$aARTICLE
000143219 245__ $$aProstaglandins and the synergism between VIP and noradrenaline in the cerebral cortex
000143219 269__ $$a1987
000143219 260__ $$c1987
000143219 336__ $$aJournal Articles
000143219 520__ $$aWe have previously shown that vasoactive intestinal peptide (VIP) and noradrenaline (NA) interact synergistically to increase cyclic AMP levels in mouse cerebral cortical slices. The pharmacological mechanism of this synergism is the potentiation by NA, through alpha 1 adrenergic receptors, of the stimulatory effect of VIP on cAMP formation. A similar interaction has been confirmed in guinea pig cerebral cortex and in discrete nuclei of the rat hypothalamus. Furthermore VIP and NA interact synergistically to depress the spontaneous activity of identified neurons in rat neocortex. At the cellular level, this synergistic interaction suggests that VIP- and NA-containing neuronal systems may converge, at least in part, on the same target cells to increase cAMP levels in the cerebral cortex. At the molecular level, the interaction may occur at various steps in signal transduction, between receptors, intramembrane transduction processes or intracellular effector mechanisms. Here we report that the alpha 1-adrenergic potentiation of the increases in cAMP elicited by VIP involves the formation of arachidonic acid metabolites and is mimicked by prostglandins F2 alpha and E2.
000143219 700__ $$aSchaad, N C
000143219 700__ $$aSchorderet, M
000143219 700__ $$0243698$$aMagistretti, P J$$g134990
000143219 773__ $$j328$$k6131$$q637-40$$tNature
000143219 909C0 $$0252265$$pLNDC$$xU11150
000143219 909CO $$ooai:infoscience.tind.io:143219$$particle$$qSV
000143219 937__ $$aLNDC-ARTICLE-1987-003
000143219 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000143219 980__ $$aARTICLE