Synthetic Studies on the Sporolides: Exploration of the Enediyne Route

Synthetic studies towards the construction of the cyclopenta[a]indene fragment of the heptacyclic marine metabolite sporolide are reported based on a hypothetical biosynthesis. The key step of this biogenetic proposal includes a Bergman cyclization of an enediyne precursor. The enediyne target of this synthetic study was prepared by Sonogashira cross-coupling of two fragments, of which the cyclopentane fragment was prepared from cyclopentenone, Morita-Baylis-Hillman reaction, and enantioselective Sharpless dihydroxylation.


Publié dans:
Synthesis, 4, 631-642
Année
2010
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 Notice créée le 2009-12-17, modifiée le 2018-03-17


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