Direct Alkynylation of Indole and Pyrrole Heterocycles

Easy does it: The unique properties of benziodoxolone alkynyl periodinane 1 and gold catalysts have allowed the development of a high yielding, operationally simple (room temperature, no dry solvents or inert conditions, commercially available catalyst) reaction for the introduction of silylacetylenes on a large range of indole and pyrrole heterocycles with a wide range of functional groups (see scheme).


Published in:
Angewandte Chemie, International Edition, 48, 49, 9346-9349
Year:
2009
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 Record created 2009-11-19, last modified 2018-01-28

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