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  4. Diffusion of Single Molecules in Nanochannels
 
conference poster not in proceedings

Diffusion of Single Molecules in Nanochannels

Dellagiacoma, Claudio  
•
Durand, Nicolas F. Y.
•
Goetschmann, Raphaël
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2009
Biomedical Photonics Network day 2009 (BMPN)

With fluorescence correlation spectroscopy (FCS), the diffusion and concentration of proteins (wheat germ agglutinin) in a nanofluidic system are measured on a single molecule level. By increasing the ionic concentration, the Debye length of the electrical double layer (EDL) decreases altering the strongly enhanced surface interactions of charged proteins in nanochannels. A theoretical model of the transport of charged mole- cules in nanofluidics facilitates the design of future nanochannel applications.

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