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In a globalized space where mobility is growing, the capacities of attraction of the city are becoming increasingly decisive. Between the cities, through its attractive quality and attraction capacity, the university will become a decisive factor of location activity. The contribution of the capacity of city culture, development of meeting places is fantastic. Universities cannot live permanently on their side, next to the city. However, for too long, the city and the university in Tunisia have developed in ignorance of each other. Universities, since they have existed, admit with difficulties contingencies of civil societies. Governments are wary of students and teachers. This latent divorce materialized especially through the creation of campus, away from city centers in the functionality and the monotony of isolation. The urban university countdown is now universally condemned. Addressing universities as major facilities for both generating modern middle classes and meet the needs of these classes is probably a new perspective in the architectural and urban studies in Tunisia. Investigate the essence of the university and its space, understand, give it a face, it takes to trace the sources of the university, the genesis of the position in relation to our time, in any its specificity, to lay a few landmarks able to give an account for the complexity of its course. Why, how, by whom and under what conditions taking shape at a given time an edifice (the university) from a social vocation? What general needs and specific answers? In short, what is the territorial space that University now covers? In this sense, the systemic approach presents an additional interest because it proposes to connect into a single and same application dimensions of reality that are sometimes addressed separately by different disciplines and different actors, professional town planning, culture, life student or teaching. Indeed, we have chosen to begin this research by presenting a sample of general policies of academic development in an international perspective. In a second stage, we will continue research on the same theme, but by focusing it on Tunisia. In this context, we will consider the current inadequacy between the university and the changing needs of society. In the third part, we will study the spatial impact and synergy between the university and the economic environment. This theme is central to the debate on the complex interactions of urban dynamics and local development. We will conclude by reviewing the first two parts in the light of the results of the third. Furthermore, this research involved a provision of knowledge, which is able to provide solid foundations for working professionals in architecture and urban, social scientists, lawyers, economists and current officials in charge to define strategies and projects of agglomeration.